219-225 Karmarkar LAJP 1626:Karmarkar
نویسندگان
چکیده
Fenofibrate is more effective drug as compared to other fibrates. But low bioavailability of it is due to its poor aqueous solubility. The purpose of present study was to improve fenofibrate dissolution through its formulation into liquisolid tablets and then to investigate in vitro performance of prepared liquisolid systems. By use of this technique, liquid medications such as solutions or suspensions of water insoluble drugs in suitable non-volatile liquid vehicles can be easily converted into powders with acceptable flow properties and compression behavior by using suitable powder excipients. X-ray powder diffraction and Differential Scanning Calorimetry were used for evaluation of physicochemical properties of Fenofibrate in liquisolid tablets. Stereomicroscopy was used to assess morphological characteristics of liquisolid formulation. Enhanced drug release profiles due to increased wetting properties and surface of drug available for dissolution was obtained in case of liquisolid tablets.
منابع مشابه
538-543 Karmarkar LAJP 1720:Karmarkar
The present work deals with the comparison of in vitro dissolution profiles of fenofibrate liquisolid tablet formulations with those of marketed fenofibrate tablets, and the application of statistical methods to evaluate each method for its usefulness. The methods used to study dissolution profile comparison include Model independent method (Similarity factor, f2); Model dependent methods (Zero...
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